I am signing up because I got recommendation for the call for young scientists.
I think it would be a great honor and networking with other people in the field will help me develop a broad scientific view enabling me to collaborate with other people in the field.

Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective antiobesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to patients with obesity and observed a heightened sense of preingestive satiation. Analysis of human and mouse brain samples pinpointed GLP-1 receptor (GLP-1R) neurons in the dorsomedial hypothalamus (DMH) as candidates for encoding preingestive satiation. Optogenetic manipulation of DMHGLP-1R neurons caused satiation. Calcium imaging demonstrated that these neurons are actively involved in encoding preingestive satiation. GLP-1RA administration increased the activity of DMHGLP-1R neurons selectively during eating behavior. We further identified that an intricate interplay between DMHGLP-1R neurons and neuropeptide Y/agouti-related peptide neurons of the arcuate nucleus (ARCNPY/AgRP neurons) occurs to regulate food intake. Our findings reveal a hypothalamic mechanism through which GLP-1RAs control preingestive satiation, offering previously unexplored neural targets for obesity and metabolic diseases.

Currently, I am interested in pursuing the neurobiology of hunger. Especially, I am interested in how hunger is controlled by our daily 'food thoughts' and the underlying neural circuits that regulate this. This is particularly important as there are reports showing that GLP-1RA treated people have decreased 'food noise' which is highly linked to individuals being tempted to consuming excessive foods.