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Entry Information

PART 1: PERSONAL PARTICULARS

Name

Shunsuke Saito

Title

Dr

Gender

Male

Recent Photo

Recent Photo

Date of Birth

02/09/1991

Place of Birth

Japan

Type of Identity Document Held

Passport

HKID / Passport Number

TT210

Nationality

Japanese

PART 2: CONTACT INFORMATION

Email Address

Email hidden; Javascript is required.

Contact Phone Number

+81757534576

Address

46-29 YOSHIDA-SHIMO-ADACHI-CHO,
Kyoto
Japan

PART 3: FORUM INTEREST

Name of Recommending Laureate / Academic

Prof Kazutoshi Mori

First Discipline to be Joined

Life Science and Medicine

Second Discipline to be Joined

N/A

Statement of Purpose to Join the Forum (max. 200 words)

I hope to participate in this forum to interact with other outstanding researchers from around the world, and gain excellent insights for my future research.

PART 4: ACADEMIC AND/OR RESEARCH INFORMATION

Academic Level / Position

Postdoc

Academic Subject / Research Field

Cell Biology

Current Affiliated University / Institution / Organisation

KUIAS KYOTO UNIV

Location

Kyoto

Resume

Resume

Transcript 1

Transcript 1

First Academic or Research Referee *

First Referee Name

Kazutoshi Mori

First Referee University

Kyoto University

First Referee Position

Professor

First Referee Email Address

Email hidden; Javascript is required.

Second Academic or Research Referee

Award(s) and/or Scientific Accomplishment(s) (if any) (max. 100 words)

Two Awards & One Competitive Grant ( https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23K19349 )

Reference/Certificate of Award and/or Scientific Accomplishement

The Japanese Biochemical Society Kinki Branch / The Japanese Society of Carbohydrate Research / Japan Society for the Promotion of Science

Reference / Certificate of Award and / or Scientific Accomplishment Supporting Document

Reference / Certificate of Award and / or Scientific Accomplishment Supporting Document

Translation of Reference / Certificate of Award and / or Scientific Accomplishment Document

Translation of Reference / Certificate of Award and / or Scientific Accomplishment Document

Publication List (if any)

Publication List (if any)

Abstract of Research / Brief Description of Your Current Research Interest (max. 200 words)

I am investigating the mechanism of how the ER stress initiates and/or progresses motor neuron diseases, including ALS and Seipinopathy. Previously I revealed that aggregates of the ER membrane protein ngSeipin, a causal mutant protein of Seipinopathy, incorporate and inactivate ER calcium ion pomp SERCA2b, thereby inducing ER stress and cell death (Saito et al., Elife, 2022). And in my recent study, I found that ATF6-branch, one pathway of the Unfolded Protein Response (UPR), protects cell from ngSeipin not only by transcriptional induction of BiP, one of the most important ER chaperones, but also by optimization of its availability. In this forum, I would like to show you the new mechanism of how some of ATF6-target proteins realize optimal anti-aggregation effect of BiP.

Would you like to present your Research in Poster Presentation Session and/or Flash Presentation?

Both Sessions

PART 5: OTHERS

Did you participate in the inaugural Hong Kong Laureate Forum?

N/A

How Did You Know About the Forum?

Professor