As a PhD researcher investigating epigenetic inheritance mechanisms in maternal-fetal health, I am passionate about deciphering how 3D genome organization and cellular heterogeneity contribute to intergenerational disease transmission. My work integrates single-cell transcriptomics and spatial profiling to understand how metabolic and endocrine conditions reshape the epigenetic landscape across generations.
The Hong Kong Laureate Forum represents an extraordinary opportunity to engage with pioneering scientists whose work has transformed our understanding of biological mechanisms. I am particularly inspired by Professor Peter Walter's recent contributions to maternal exposure and offspring health—research that directly intersects with my interests in epigenetic programming.
Attending this forum would allow me to gain invaluable insights from laureates, establish connections with fellow early-career researchers, and broaden my scientific perspective across disciplines. These interactions would profoundly influence my approach to investigating complex epigenetic mechanisms.
I have long aspired to experience Hong Kong's vibrant academic environment. Despite getting a research assistant position at Hong Kong Baptist University in 2020 and a valid EEP, my plans were derailed by the pandemic. Participating in this forum would fulfill this ambition while nurturing my development as a scientist dedicated to understanding transgenerational health determinants.

Karolinska Institute

My research focuses on deciphering the epigenetic landscape and its transgenerational implications in health and disease. Drawing from my expertise in 3D chromatin organization and transcriptional regulation, I investigate how structural genomic alterations influence gene expression patterns across development and in pathological conditions.
During my master's research, I characterized chromosome conformational changes during mouse spermatogenesis and classified topologically associating domains (TADs) based on transcriptional activity and chromatin states. My PhD work extended this epigenetic perspective to placental dysfunction in polycystic ovary syndrome and obesity, revealing how maternal metabolic conditions reshape placental cellular transcriptomes and affect fetal programming.
My current research interest lies at the intersection of these fields—exploring how epigenetic modifications, particularly 3D genome organization, serve as a molecular bridge connecting environmental exposures to disease phenotypes across generations. By integrating multi-omics data (Hi-C, RNA-seq, ATAC-seq, ChIP-seq, and single-cell technologies), I aim to construct comprehensive models of epigenetic landscapes that explain transgenerational inheritance of metabolic and reproductive disorders. This work has significant implications for understanding disease etiology and developing targeted interventions that address the epigenetic underpinnings of complex disorders.