As a young scientist passionate about advancing knowledge and innovation in visual neuroscience, I am eager to join the Hong Kong Laureate Forum. This event offers a rare opportunity to engage with world-renowned researchers and gain first-hand insight into their groundbreaking work and scientific spirit.

I am also enthusiastic about presenting my research project to an international audience of peers and senior scientists. Through meaningful exchange of ideas, I hope to receive valuable feedback, broaden my perspectives, and refine my research approach. The dynamic environment of the Forum will facilitate vibrant discussions, potentially leading to new scientific directions and enhancements in my current work.

Furthermore, I am excited about the potential for interdisciplinary collaborations. By connecting with brilliant minds across diverse fields, I aim to explore synergies between disciplines, spark innovative research ideas, and build academic relationships and networks. Participating in the HK Laureate Forum will be an invaluable experience that contributes to my growth as a researcher and to the scientific community at large.

Hong Kong Polytechnic University

My current research focuses on exploring the mechanisms of neurodegeneration and neuroprotection in animal models of human retinal diseases, such as retinitis pigmentosa and glaucoma. Unlike conventional strategies that directly target photoreceptors or retinal ganglion cells, my work introduces an innovative approach centered on modulating neuroimmune cells—particularly microglia. I have identified and studied several key regulatory molecules, including CD33, Trem2, and TAK1, aiming to manipulate microglial behavior to achieve neuroprotection in degenerative retinal conditions.

In parallel, I am conducting pioneering work on the development of advanced gene therapy tools for ocular diseases. Specifically, I am engineering adeno-associated viruses (AAVs) with enhanced specificity for microglia, enabling targeted delivery of therapeutic genes to modulate immune responses and preserve retinal function.

Additionally, I employ single-cell RNA sequencing (scRNA-seq) to investigate the cellular and molecular mechanisms underlying various eye diseases. This includes not only retinal disorders, but also corneal diseases and myopia. By combining neuroimmunology, gene therapy, and cutting-edge genomics, my research aims to uncover novel therapeutic strategies for vision preservation and restoration.