I am Aastha Sharma, currently pursuing my PhD in Medical Microbiology at the Faculty of Medicine, Universiti Malaya, Malaysia. With a strong academic foundation in microbiology and a passion for interdisciplinary research, I am eager to join the 2nd Hong Kong Laureate Forum to engage with global leaders in science and fellow young researchers.

My research primarily focuses on microbiota and its influence on health and disease, including reproductive health. The Laureate Forum offers an invaluable opportunity to broaden my scientific horizons through intellectual exchange, workshops, and poster presentations. I am especially enthusiastic about learning from the Shaw Laureates and exploring innovative approaches in scientific collaboration.

Participating in this forum will not only deepen my understanding of current global scientific challenges but also refine my vision as a future scientist. I believe that meaningful interactions across disciplines and cultures are essential for scientific advancement, and I am committed to contributing to and learning from this global platform.
The forum's emphasis on both scientific excellence and cross-cultural dialogue aligns perfectly with my academic goals and personal values. I look forward to representing my institution and collaborating on

Background: Polycystic Ovary Syndrome (PCOS) is a complicated endocrine and metabolic condition that is often characterized by polycystic ovaries, hyperandrogenism, and ovulatory dysfunction. PCOS is considered a multifactorial disorder with various genetic, endocrine and environmental abnormalities. Recent data indicates that PCOS may be passed down over generations rather than being limited to a single generation, possibly via microbial, metabolic, and epigenetic mechanisms. Objective: This narrative review aims to explore PCOS as a transgenerational impact also influencing the gut microbiome and its role in mediating its pathophysiology. Method: Research from human and animal models, including those that use letrozole, DHEA, or prenatal androgen exposure, will be examined and consistently identify indications of gut dysbiosis, or unbalanced gut flora, associated with issues related to metabolism and reproduction. Result: The review describes mechanism of gut micro-organisms impact on the immune system, hormones and metabolism, contributing to PCOS and aims to provide knowledge on the role of microbes in generational transmission of PCOS.Conclusion: Gut microbiota plays an important role in development and generational transmission of PCOS. Hence, insight into gut microbiota can help the pathophysiology of PCOS and might lead for microbiome-targeted therapies.