I hope to participate in the Hong Kong Laureate Forum 2025 to learn about the research content and ideas of world-class experts in the field of science, especially in the field of life sciences and medicine. In addition, I will actively communicate with young researchers in different disciplines (astronomy and mathematical sciences) to expand the ideas of interdisciplinary research and explore potential cooperation directions. In particular, in the study of the mechanism and regulation of locomotor system diseases, I hope to use cutting-edge scientific progress to solve the dilemma of treatment of locomotor system diseases in clinical medicine.In terms of cross-sectional research, we originally reported in Nature in the previous period that the treatment of osteoarthritis in mice was realized by using the cross-species transplantation of plant photosynthesis system into mammalian cells. We hope to communicate and cooperate with domestic and foreign experts in this field through this forum.

An inadequate intracellular anabolism is a key factor contributing to almost all pathological processes in the body. The anabolic metabolism of intracellular substances relies on the sufficiently consumption of intracellular energy and reducing equivalents. In this study, inspired by the process of plant photosynthesis, we developed a unique and controllable nanoscale plant-derived key photosynthetic system CM-NTUs, in which nanothylakoid units (NTUs) were encapsulated by specific mature cell membranes, such as Chondrocyte membrane (CM) for immune evasion. These CM-NTUs could enter chondrocytes through membrane fusion without being degraded by lysosomes, and rapidly penetrate tissue through intercellular transport. Moreover, CM-NTUs increased intracellular ATP and NADPH levels in situ via controllable light exposure, systemically correcting cell energy imbalance and restore cellular metabolism to improve cartilage homeostasis and protecting against pathological progression of osteoarthritis.